Seedlings and rosettes of prickly lettuce are easily controlled by cultivation. Mowing of rosettes is not an effective control practice because leaves lie close to the soil surface. If mowing occurs after stem elongation the plant will simply produce new stems and flowers
Biological: Sheep and goats enjoy feeding on prickly lettuce and will devour whole fields of this weed.
Chemical: Rosettes of prickly lettuce can be controlled in the fall or spring by non-selective herbicides containing glyphosate, glufosinate, or paraquat, however, populations of prickly lettuce are extremely tolerant of glyphosate herbicide. Plants are difficult to control with herbicides once the flowering stems have begun to elongate. Preemergence applications of products containing atrazine, metribuzin, chlorsulfuron, isoxaben, oxyfluorfen, oxadiazon or terbacil will usually control germinating seedlings. Postemergence applications of 2,4-D, MCPA, dicamba, chlorsulfuron+metsulfuron, pyrosulfotole, bromoxynil, clopyralid, metribuzin, tribenuron or thifensulfuron-methyl/tribenuron-methyl, can control prickly lettuce rosettes in a variety of crops.